​Nutraceutical and vitamin formulations can be very challenging due to a variety of factors including numerous active ingredients which create formulating challenges, flow compressibility moisture sensitivity and ingredient interaction. SYLOID® FP silicas are highly porous, micronized silica powder, and are effective when used as carriers for active ingredients due to their high adsorption capacity, controlled desorption, and improved compatibility.

The multifunctional properties of SYLOID® FP silica is effective in nutraceutical and supplement  formulations in a range of applications including: glidants, tabletting aids, suspension aids, disintegrants, and dragees. In addition, they also provide other benefits to formulations such as:

  • Prevent clumping
  • Maintain free-flow behavior
  • Improve process ability and homogeneity
  • Control moisture
  • In general, extend the shelf life of powdered products and ingredients.

SYLOID® and PERKASIL® silicas are particularly suited for formulating powder-based nutritional supplements. In bulk powder applications, maintaining a free-flow behavior during processing is critical to minimize downtime and ensure product quality and homogeneity. Free-flow describes the ability to maintain the powder velocity once it is in motion. In this respect,

Grace's SYLOID® and PERKASIL® silicas act as free-flow agents for powder-based supplements and serve the following functions:

  • Prevent packing of particles and act as a physical barrier upon compaction
  • Coat and smooth the edges of bulk powders reducing inter-particle friction
  • Adsorb excess moisture from the atmosphere before it can be absorbed by the bulk powder
  • Adsorb moisture and oil diffusing out of the bulk powder


Fine Chemical Manufacturing Specializing in Regulatory Starting Materials and Advanced Intermediates


Grace partners with customers to solve complex challenges in custom chemical synthesis and the scale up of fine chemicals for the pharmaceutical, nutraceutical, food and beverage, chemical processing, and other industries. High quality, made-to-order compounds can be manufactured in quantities ranging from kilos to tons delivered on time and upholding the highest Western safety and quality standards.

Grace works with customers to support projects from pre-clinical through commercialization, offering customized product development, project management, and scale-up expertise. With a deep understanding of organic synthesis and biocatalysis supported by a comprehensive cGMP environment Grace provides vital building blocks for a range of products: technology based regulatory starting materials, advanced intermediates, and organic chemical materials including synthetically challenging nutraceutical compounds not accessible via traditional extraction from natural sources.

Click here​ for additional information about our Fine Chemical manufacturing.

Grace's silicas are of high purity, chemically inert, and are very efficient in helping to ensure free-flow, even for the most troublesome powdered supplement products.


​Grade

​Unit

​​​​SYLOID® Silica Gels​ ​ ​ ​​

​PERKASIL® Silica

​SYLOID®
​244 Silica​

​SYLOID®
72 Silica​

​SYLOID® 
63 FP Silica​

​SYLOID® 
72 FP Silica​

SYLOID®
244 FP Silica​

​Particle Size Malvern

​µm

​6.5

​6

​6

​6

​5.5

​16

​Loss on Drying (105° C)​

​%

​7.0 max

​7.0 max

​Loss on Drying (145° C)

​%

​​5.0 max

​​5.0 max

​​5.0 max

​Loss on Ignition (1000° C)

​%

​​8.5 max

​​8.5 max

​​8.5 max

​​8.5 max

​​8.5 max

​​8.5 max​

​Oil Absorption

​g/100g

​280

​200

​90

​220

​300

​240

​Pore Volume

​Cc/gm

​1.5

​1.1

​0.4

​1.2

​1.5

​1.2

​Surface Area

​M2/gm

​300

​350

​700

​350

​300

​190

​pH (5% H2O Slurry)

​7.0

​7.0

​4.7

​6.7

​7.0

​7.0

​Bulk Density

​Ib/ft3

​6.3

​10.0

​29.0

​10.0

​6.2

​7.0

​SiO2 (dry basis)

​%

​99.​4

​99.4

​99.6

​99.6

​99.6

​98.0

​Meets FCC Monograph

​Yes

​Yes

​Yes

​Yes

​Yes

​Yes

​Meets USP/NF

​No

​No

​Yes

​Yes

​Yes

​No

​INCI Classification

​Applications

​Food/Nutraceuticals​ ​

​​​Pharmaceuticals/Nutraceuticals/Food​ ​ ​

​Food/Nutraceuticals​


To select the ideal SYLOID®​ or PERKASIL® silica for your formulation requirements, consult your Grace representative.​​