​Silica-based Drug Delivery Technology 

SILSOL® silica-based drug delivery technology provides solutions for poorly soluble active ingredients. SILSOL® silica was engineered to bring together advanced silica technologies with challenging active pharmaceutical ingredients. It is based on a compendial silica that is fully scalable, giving pharmaceutical developers new options to enhance bioavailability of poorly soluble BCS2 compounds, especially during early research and discovery.

Our expertise in materials science and our long history in the pharmaceutical industry is evident in the innovative solutions and technical expertise we can provide. Grace works with our customers to develop and scale up the right materials for specific formulations. And our committed R&D and technical support teams' comprehensive understanding of industry-specific processes and issues ensure you receive the maximum value from our products. We can help you select the right SYLOID® silica product for your application.

Benefits

  • Enhanced Bioavailability – through delivery of the amorphous form of drugs
  • Stability – Amorphous solid dispersions prevent re-crystallization
  • Pharmacopoeia Acceptance – GMP manufactured silica conforms to Global monographs
  • Scalability – Grams to tons quantities under excipient GMP manufacture
  • FDA Compliance – Material is listed on the FDA inactive ingredient database

 

Advantages

Compared to other bioavailability enhancing techniques such as particle size reduction, complexation, lipid-based systems and polymer-based solid dispersions, Grace's SILSOL® Silica Technology introduces techniques that are often easier to screen, less complex to make, and require less time when scaling up. 

  • Suitable for NCE, life cycle management, reformulations, and repositioning
  • Applicable to a broad range of compounds (including all BCS2 poorly solubles)
  • Easy and cost-effective introduction into established manufacturing units
  • Generate stable formulations

​Our expertise in materials science and our long history in the pharmaceutical industry is evident in the innovative solutions and technical expertise we can provide. Grace works with our customers to develop and scale up the right materials for specific formulations. Our committed R&D and technical support teams' comprehensive understanding of industry-specific processes and issues ensure you receive the maximum value from our products. 

Contact Grace for help selecting the right product fo​r your formulation or application.