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Pharma & Biopharma

     

​Extract-Clean™ SPE Columns

 

General purpose SPE columns with a broad selection of phases including a complete offering of reversed-phase, normal-phase, ion-exchange and specialty columns including carbograph, phase separator and filter columns.

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 Extract-CleanTM Sorbent Specifications

 Reversed-Phases (Non-Polar) Sorbent Specifications  ​ ​ ​ ​ ​ ​ ​
 Functional Group  Base  % Carbon End- capped Average Particle Size Pore Size  Features  Benefits 
Prevail™ C18 Silica  11.0%  Yes  50μm  60Å 100% water wettable Hydrophilic/hydrophobic retention. Phase remains active even when completely dry. Can omit preconditioning step. 
Standard C18 Silica  6.0%  Yes  50μm  60Å Low carbon load C18 General purpose phase. 
High-Flow C18 Silica  8.0%  Yes  100μm  60Å Large particle Less flow resistance for faster flow rates of large volume sample. 
High-Capacity C18 Silica  17.0%  Yes  50μm  60Å High carbon load Maximum capacity phase. 
Octyl (C8) Silica  4.5%  Yes  50μm  60Å Less hydrophobic than C18 Less retention of highly hydrophobic compounds. Use when C18 is too retentive. 
Normal-Phases (Polar) Sorbent Specifications  ​ ​ ​ ​ ​ ​ ​
 Functional Group  Base % Carbon End- capped Average Particle Size Pore Size  Features  Benefits 
Silica (SI) Silica  —  —  50μm  60Å Highly polar surface Most common polar phase. 
Aminopropyl (NH2) Silica5.0%  No 50μm  60ÅPolar phase with slight anion exchange properties Ideal for carbohydrates or generally with analysis containing hydroxyl functional groups. 
Cyanopropyl (CN) Silica  6.0%  Yes  50μm  60Å Unique selectivity Can be used in normal-phase or reversed-phase modes. 
Diol (2OH) Silica  4.0%  No  50μm  60Å Polar surface with minor hydrophobic retention Wets easily and offers more reproducibility.​
Florisil® (FL)  Magnesium Silicate  —  —  75–150μm  60Å Highly polar surface Referenced in many EPA methods.  Ideally suited for pesticides and metals. 
Alumina Basic (AL-B) Aluminum Oxide  —  —  130μm  100Å Alumina washed with base surface Increase capacity for basic compounds. 
Alumina Neutral (AL-N) Aluminum Oxide  —  —  130μm  100Å Alumina washed with neutral surface Interacts with highly aromatic compoundsand neutral hydroxyls. 
Ion-Exchange Sorbent Specifications  ​ ​ ​ ​ ​ ​ ​
Packing  Base  Counter Ion Particle Size Functional Group Exchange Capacity  Retains Applications 
SCX  Styrene-DVB  Hydrogen  50μm  Benzene Sulfonic Acid  2.0meq/mL Cations, (+) charged compounds Remove/concentrate basic compounds 
SAX  Styrene-DVB  Acetate  50μm  Tetramethyl Ammonium  1.0meq/mL Anions, (–) charged compounds Remove/concentrate basic compounds 
Ion Chromatography Sorbent Specifications  ​ ​ ​ ​ ​ ​ ​
Packing  Base  Counter Ion Particle Size Molecular Exclusion Limit Exchange Capacity  Retains Applications 
IC-OH Styrene-DVB  Hydroxide 50μm  1000 Daltons 1.0meq/mL  Anions Exchanges anions for hydroxide. May be used to remove or concentrate anions from sample and to increase pH of acidic samples. Removes cations that form insoluble hydroxide salts.
IC-H Styrene-DVB  Hydronium  50μm  1000 Daltons 2.0meq/mL  Cations  Exchanges cations for H+. May be used to remove or concentrate cations from sample and to reduce pH of basic samples. 
IC-Ag Styrene-DVB  Silver  50μm  1000 Daltons 2.0meq/mL Chloride Iodide Bromide  Removes excess halides through formation of Ag-halide salts. 
IC-Ba  Styrene-DVB  Barium  50μm  1000 Daltons 2.0meq/mL  Sulfate  Removes excess sulfate through formation of BaSO.
IC-Na​Styrene-DVB Sodium  50μm1000 Daltons2.0meq/mLCationsExchanges cations for Na+. May be used to remove or retain cations from sample without changing the pH of the sample.
IC-Chelate Styrene-DVB  Sodium  50μm  1000 Daltons 0.4meq/mL Polyvalent metal ions  Exchanges transition metals and divalent cations for Na+. May be used to remove or retain divalent cations and transition metals from sample. 
IC-RP Polystyrene  —  550μm  —  — Hydrophobic components Removes surfactants, organic acids, and other organic substances. Inorganic ions pass through. 
Specialty Packings Specifications  ​ ​ ​ ​ ​ ​ ​
Packing Base  % Carbon End- capped Average Particle Size Pore Size  Features Benefits 
DVB 100% DVB  —  —  40μm  —  100% DVB Greater capacity than C18 for general SPE. Also free vinyl surface groups makea suitable solid-phase synthesis support. 
Carbograph Graphitized Carbon  —  —  38–125μm  — Graphitized carbon Retains polar organics in aqueous matrices. Ideally suited for acid, base-neutral extraction of pesticides and herbicides. 
AFT C18, Silica, and Alumina  6  —  50–130μm  —​Unique blend of reversed and normal phases Ideal for Aflatoxins. 
Phase Separator Columns​ ​Use for fast and simple separation of organic and aqueous mixed samples. The column contains a 20um polyethylene frit and a hydrophobic silicone membrane that allows the hydrophobic phase to pass through, while the aqueous phase is retained in the upper chamber.
Filter Columns​ ​​Filter columns are Extract-CleanTM reservoirs with two frits a the outlet end.  They remove particulate matter down to 20um from samples.  Syringe adapters will connect filter columns to the tops of Extract-CleanTM columns. ​
Drying Tubes ​Packed with anhydrous sodium sulfate, use these to remove residual water from SPE extracts.  They are suitable for pesticide analysis.​ ​ ​ ​ ​ ​