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DAVISIL® Chromatographic Silica

DAVISIL® chromatographic silica is a standard for purification in a variety of industries

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DAVISIL® chromatography resins for small to large molecule purification.

Grace sets the industry standard for pure, consistent, high-quality bulk silicas for purification, separations, and a wide range of chromatographic applications.

Our superior technology and scale-up capabilities make Grace the expert for pharmaceutical and nutraceutical companies throughout the product development and commercial manufacturing process. Grace has a broad portfolio with the ability to scale to commercial scale volumes complimented by extensive experience in bonding different resins.

Manufactured for almost 40 years, DAVISIL® chromatographic silica is one of the world's most widely used chromatography resins and a standard for purification in a variety of industries. DAVISIL® silica is produced at two ISO-9001 certified facilities under strict QC controls from raw material to finished product for optimized chromatographic performance. Each step in the production process is closely monitored to proactively eliminate variability and better ensure high lot-to-lot finished product reproducibility and tightly controlled specifications for dependability and continuity over the long term.

DAVISIL® silica grades are available in a wide range of particle and pore sizes and in many bonded phases, from small to multi-ton quantities to meet your application, performance, and economic requirements. DAVISIL® chromatography resins can be used for a wide range of purification applications including:

  • Vitamins & Nutraceuticals
  • Antibiotics & Vaccines
  • Oil-based APIs
  • Organic Synthesis
  • De-colorization
  • Lipids
  • Enzymes
  • Biomolecules
  • Vaccines

The unique "extra-wide pore" DAVISIL® XWP silica grades are specially designed with superior mechanical stability and large pore sizes with narrow pore size distribution, which makes them optimal for separations of large biological molecules.

DAVISIL® Sphere chromatography resin: unique spherical monodisperse silica.

DAVISIL® Sphere silica is based on a unique spherical monodisperse silica that is extremely robust with narrow particle size distribution. This means you will experience highly reproducible and superior chromatographic performance that does not degrade over time. DAVISIL® Sphere silica can offer unique selectivity compared to other reversed-phase resins on the market to help resolve components that others cannot.

DAVISIL® Sphere chromatography resin is recommended for the separation of:

  • Small molecules
  • Peptides less than 4,000-5,000 MW
  • Natural and synthetic peptides
  • Oligonucleotides

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