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Bulk Chromatography Resins​​​

Contact us to request a sample and learn more about Grace's chromatography resins.

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Grace sets the industry standard for pure, consistent, high quality bulk chromatographic resin for purification, separations, and a wide range of chromatographic applications. Our superior technology and scale-up capabilities make Grace the ideal partner for pharmaceutical and nutraceutical companies throughout the product development and commercial manufacturing process. Grace has a broad portfolio with the ability to scale to commercial scale volumes complimented by extensive experience in bonding different resins. 

  • The widest range of pore diameters and particles sizes
  • A selection of normal and reversed phases (C1, C2, C4, C8, C18, Phenyl, Amino, Diol, Cyano), ion exchange, and other chemistries.
  • Batch-to-batch consistency and reproducibility.
  • Scalability: Resins that can be used from analytical lab scale all the way through commercial scale .
  • ISO 9001 certified (SGS #US14/841829). Halal and Kosher certified, and FDA registered (#15439296164)

Davisil® Chromatography Resin: For Small to Large Molecules​​


DAVISIL® Chromatography Resins Can Be Used for a Wide Range of Purification Applications Including:

  • Vitamins & Nutraceuticals
  • Antibiotics & Vaccines
  • Oil-based APIs
  • Organic Synthesis
  • De-colorization
  • Enzymes
  • Biomolecules​
Manufactured for over 25 years, DAVISIL® chromatographic silica is one of the world's most widely used chromatography resins and a standard for purification in a variety of industries. DAVISIL® silica is produced at two ISO-9001 certified facilities under strict QC controls from raw material to finished product for optimized chromatographic performance. Each step in the production process is closely monitored to proactively eliminate variability and better ensure high lot-to-lot finished product reproducibility and tightly controlled specifications for dependability and continuity over the long term.

DAVISIL® silica grades are available in wide range of particle and pore sizes and in many phases from small to multi-ton quantities to meet your application, performance, and economic requirements. The unique "extra wide pore" DAVISIL® silica grade is specially designed for large molecules commonly purified in bioseparations. ​


New DAVISIL® SPHERE CHROMATOGRAPHY RESIN: Unique Spherical Monodisperse Silica

  • Superb mechanical stability
  • Monodisperse characteristics enable packing ease
  • Unpack and reuse without performance degradation
  • Excellent chromatographic performance
  • Lower pressure drop - 2x lower than leading resin
  • Extended column lifetimes
  • Scale to prep and process applications

DAVISIL®​ Sphere silica is based on a unique spherical monodisperse silica that is extremely robust with narrow particle size distribution. This means you will experience highly reproducible and superior chromatographic performance that does not degrade over time. DAVISIL®​ Sphere silica can offer unique selectivity compared to other reversed phase resins on the market to help resolve components that others can't. 

DAVISIL® Sphere chromatography resin is recommended for the separation of:

  • Small molecules
  • ​Peptides less than 4,000-5,000 MW
  • Natural and synthetic peptides​
  • Oligonucleotides

VYDAC® Chromatography Resin: The Trusted Brand for Biopurification​

Grace pioneered one of the first media platforms for reverse phase protein and peptide separation as well as polishing steps in bioprocessing. Produced by a unique process based on purified organosilicate starting materials, VYDAC® spheroidal silicas are a well-defined, highly pure, and totally porous separation resin for preparative and process scale users and have excellent selectivity and reproducibility.

Referenced in more than 9000 patents, VYDAC® TP resin is the 300Å phase to which all others are compared. It is relied upon in drug development for protein purification and is completely scalable to commercial-scale ton quantities. High recovery of proteins makes this product more cost-effective than less expensive alternatives and it is available in a wide range of bonding chemistries. 


​​VYDAC® Packed Columns 

Pre-packed analytical-scale columns are available through our exclusive partner HiChrom at For pre-packed VYDAC® preparative and proces​s-scale columns, or other packing services, contact Dr. Maisch GmbH at​


​​Learn More About Our VYDAC® Chromatography Resins Portfolio​

VYDAC® 219TP Diphenyl resin​​Recommended for the separation of:
  • Polypeptides with aromatic side chains
  • Large, hydrophobic proteins
  • ​Lipid peptides
  • Membrane-spanning peptides
  • Fusion proteins from inclusion bodies 
VYDAC® 214TP C4 resinRecommended for the separation of:
  • Polypeptides larger than 4000-5000 MW
  • Very hydrophobic polypeptides of any size 
VYDAC® 208TP C8 resinRecommended for the separation of:
  • Polypeptides up to 10,000-20,000 MW
  • Enzymatic digest fragments
  • Natural and synthetic peptides 
VYDAC® 218TP and 238TP C18 resinsRecommended for the separation of:
  • Peptides less than 4,000-5,000 MW
  • Enzymatic digest fragments
  • Natural and synthetic peptides ​


Paramagnetic Silica


Grace's paramagnetic silica is a novel particle design that clads a paramagnetic core with silica. Effective biomolecule purification can be achieved by applying a magnetic field. The silica surface can be functionalized for specific binding properties.  Particle capture by magnets can eliminate the need for chromatography, centrifugation, or vacuum filtration steps required in typical biomolecule purifications.



Custom Bonding Services: Our Resin or Yours​

With 95 years of silica manufacturing expertise and more than 45 years of chromatography experience, our long history in the pharmaceutical industry is evident in the innovative solutions and technical services we provide such as custom bonding.

If you don't see the product you are looking for, contact us to explore development of customized products to suit your specific needs including custom bonding of Grace's or your chromatography resin:

  • Custom bonding of Grace's silica (30Å-4500Å; 5μm to 200μm)

  • Custom bonding of other resins

  • Reversed and normal phase functionalities (e.g.: C18, Amino, Diol Cyano)

  • Ion exchange and other ligands (e.g.: SAX, SCX)

  • Small or large scale quantities​


Challenge us to engineer a solution for you.

Grace is a pioneer in silica technology, and our scientists continue to develop new and customized solutions beyond our standard range of products, often in close collaboration with customers.

Grace's particle engineering capabilities allow surface, pore, and particle properties to be tuned to meet a customer's unique requirements.

Companies in the highly regulated, quality-stringent food, supplement, and pharmaceutical industries have come to depend on the high quality of Grace silicas. Our global manufacturing capabilities and secure supply chain round out a partnership you can trust.​