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Pharma

Uniquely Functional Excipients

Imagine what you could do working with a partner who can engineer products to your exact specifications and minimize the number of excipients and complexity of your formulation, while expediting manufacturing and improving the efficacy and stability of your API's final dosage form.

Our SYLOID^® mesoporous silica's particles have a unique combination of properties.

We can fine-tune parameters such as pore volume, pore diameter, pore size distribution, and internal surface area to modify the functionality and meet your exact requirements.

SYLOID^® AL-1FP/63FP silicas control trace amounts of moisture and moisture transfer from the surrounding environment which can degrade APIs or cause reactions that negatively impact drugs or decrease shelf life.
SYLOID^® G silica for glidant applications is specifically designed as a cost effective glidant in pharmaceutical formulations.
SYLOID^® 244 FP is a real multi-purpose excipient that can be used in all oral dosage drug forms and for tablet coating. It offers moisture protection, anti-tacking properties, and acts as a glidant and suspension aid.

SYLOID^® XDP silica carrier is an optimized mesoporous material engineered for transforming liquids to free-flowing solids, particularly oily actives and lipid-based systems.

Product		Benefits
SYLOID^® FP Mesoporous Silic a Excipients	SYLOID^® FP mesoporous silicas are the ideal choice for many pharmaceutical formulations due to its unique morphology to help improve the handling, adsorption, and the dissolution of many pharmaceuticals.	Effective desiccant to increase the stability of moisture-sensitive APIs Efficient conditioner for powder formulations used in suspension s Capillary wetting agent for better release and disintegration Contribution to the controlled release of active pharmaceutical ingredients (API) Low dusting and easy to handle
SYLOID^® XDP Silica Pharmaceutical Excipients	SYLOID^® XDP silica carrier is an optimized mosoporous material engineered for transforming liquids to free-flowing solids, particularly oily actives, and lipid-based systems.	Solid carrier for lipid-based drug delivery systems Transform liquids to easy to handle solids Improve bioavailability of oily actives Increase API loading in solid dosage forms Release API's quickly and completely from solid dosage forms Create liquisolid formulations
SILSOL^® Silica for Drug Delivery Systems	SILSOL^® silica was engineered to bring together advanced silica technologies with challenging active pharmaceutical ingredients to help more effectively formulate large class of poorly soluble but otherwise promising compounds.	Enhanced bioavailability - through delivery of the amorphous form of drugs Stability - amorphous solid dispersions prevent crystallization/re-crystallization Pharmacopeia acceptance - GMP manufactured silica Scalability - Grams to tons quantities FDA Compliance – Materials listed in FDA inactive ingredient database

Technical Papers

SYLOID® FP Silica	SYLOID® XDP Silica
SYLOID® F P Silicas in Pharmaceutical Film Coatings Paracetamol Tableting Properties - SYLOID® Silica vs Fumed Silica SYLOID® FP Silica Improves Flow Properties and Anti-caking Using Porous Silicas in a 2-Step Mixing Process Improves Moisture Control, API Stability, Flow Properties and Uniformity Formulation of Simethicone into Chewable Tablets SYLOID® FP Silica in Oral Dry Suspension of Antibiotics	SYLOID® XDP Silica Optimized for Liquisolid and Lipid-based Formulations SYLOID® XDP Silica Excipients Moisture Activated Dry Granulation with SYLOID® XDP Silica SYLOID® XDP Silica Carrier for PEG Nifedipine SILSOL® Silica-based Drug Delivery Silica-based Drug Delivery Technology

SYLOID® FP Silica

SYLOID® XDP Silica

SYLOID® FP Silica in Oral Dry Suspension of Antibiotics

SILSOL® Silica-based Drug Delivery

Silica-based Drug Delivery Technology

TRUST OUR RENOWNED
QUALITY AND EXACTING
STANDARDS

Grace's silica excipients are made according to Good Manufacturing Practices (cGMP) guidelines and our compendial materials meet the requirements published in the latest edition of the United States Pharmacopoeia-National Formulary (USP-NF) for Silicon Dioxide, European Pharmacopeia, and JPE monographs. SYLOID® silicas are also listed on the FDA inactive ingredient database. Additionally, we are proud to be foremost in Industry Leading Quality Standards (Excipact® -GMP).