Exceptionally innovative active ingredient delivery
Imagine what you could do if working with poorly soluble compounds was not an insurmountable issue.
Our SYLOID® and SILSOL® silicas active ingredient delivery technology combines Grace's extensive expertise in mesoporous silica gel, novel application methods, and patent-pending technologies to accelerate the screening and development of your pharmaceutical and nutraceutical formulations.
Grace's SILSOL® silica active ingredient delivery
SILSOL® silica active ingredient delivery technology solubility enhances solid dispersions, with the added benefit of doing so with compendial, scalable, and available silicas.
Grace's SILSOL® silica active ingredient delivery technology offers five major benefits
- Enhanced bioavailability through the delivery of the amorphous form of active ingredients
- Sustained stability from amorphous solid dispersions that prevent crystallization/re-crystallization
- Complies with the requirements of the latest edition of the United States Pharmacopoeia-National Formulary (USP-NF) for Silicon Dioxide and JPE monographs.
- Scalable cGMP excipient manufacturing from grams to tons quantities
- Listed on the FDA inactive ingredient database (IID)
Compared to other bioavailability enhancing techniques such as particle size reduction, complexation, lipid-based systems, and polymer-based solid dispersions, our SILSOL® silica technology introduces techniques that are easier to screen and work in combination with existing technologies to improve usage and stability, thereby reducing the time needed to scale up.
Discover our expansive, customizable portfolio
Grace's SILSOL® silica active ingredient delivery technology is used with solvent impregnation to create amorphous solid dispersions.
Due to our vast expertise in particle design, Grace can modify the pore size and surface characteristics of silica to accommodate various nutraceutical active ingredient molecules and API molecules. The net result is enhanced bioavailability with improved stability.
Today, Grace’s technology is used to deliver a wide array of flavoring agents and nutraceutical products including peppermint extract, vanilla essence, sweeteners, marine oils, probiotics, and even CBD. The net result is an enhanced flavor profile coupled with improved product stability and shelf life.
SYLOID® mesoporous silicas have been trusted solutions for drug formulations for decades and have a unique combination of properties.
Our SILSOL® silica active ingredient delivery technology accelerates the screening and development of solubility, with the added benefit of doing so with compendial, scalable, and available silicas.